Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats.

@article{Lin2011IsofluraneIH,
  title={Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats.},
  author={Daowei Lin and Zhiyi Zuo},
  journal={Neuropharmacology},
  year={2011},
  volume={61 8},
  pages={1354-9}
}
Post-operative cognitive dysfunction (POCD) is a clinical phenomenon characterized with cognitive decline in patients after anesthesia and surgery. It has been shown that interleukin-1β (IL-1β) contributes to the cognitive impairment of mice after surgery and isoflurane anesthesia. This study is designed to determine whether isoflurane alone increases inflammatory cytokines and causes cell injury and cognitive impairment. Four-month-old male Fisher 344 rats were exposed to or were not exposed… CONTINUE READING