Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain.

Abstract

Background Retrospective clinical studies suggest there is a risk for neurodevelopmental impairment following early childhood exposure to anaesthesia. In the developing animal brain, including those of non-human primates (NHPs), anaesthetics induce apoptotic cell death. We previously reported that a 5 h isoflurane (ISO) exposure in infant NHPs increases… (More)
DOI: 10.1093/bja/aex123

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Cite this paper

@article{Noguchi2017IsofluraneEF, title={Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain.}, author={Kenta Noguchi and S. A. Johnson and Gregory A. Dissen and L Diez Martin and Faro Manzella and Katie J Schenning and Jocelyn Olney and A. M. Brambrink}, journal={British journal of anaesthesia}, year={2017}, volume={119 3}, pages={524-531} }