Isoflurane bidirectionally modulates the paired-pulse responses in the rat hippocampal CA1 field in vivo.

@article{Tachibana2007IsofluraneBM,
  title={Isoflurane bidirectionally modulates the paired-pulse responses in the rat hippocampal CA1 field in vivo.},
  author={Kaori Tachibana and Koichi Takita and Toshikazu Hashimoto and Machiko Matsumoto and Mitsuhiro Yoshioka and Yuji Morimoto},
  journal={Anesthesia and analgesia},
  year={2007},
  volume={105 4},
  pages={1006-11, table of contents}
}
BACKGROUND We studied the effects of isoflurane on hippocampal synaptic transmission and paired-pulse plasticity, under in vivo intact interneuron circuitry. METHODS Using rats chronically implanted with electrodes, excitatory postsynaptic potential (EPSP) and population spike amplitude (PSA) were measured in the hippocampal CA1 field by stimulating Schaffer collaterals. The lungs of the rats were mechanically ventilated with 0.25-1.5 minimum alveolar anesthetic concentration (MAC) isoflurane… CONTINUE READING