Isoflurane and sevoflurane dose-dependently impair hippocampal long-term potentiation.

  title={Isoflurane and sevoflurane dose-dependently impair hippocampal long-term potentiation.},
  author={Rainer Haseneder and Stephan Kratzer and Ludwig von Meyer and Matthias Eder and Eberhard F. Kochs and Gerhard Rammes},
  journal={European journal of pharmacology},
  volume={623 1-3},
Isoflurane and sevoflurane are commonly used volatile anaesthetics. Although acting via similar cellular mechanisms, the effect of different volatile anaesthetics on synaptic plasticity might differ. In the present study, using acute murine brain slice preparations, we compared the effects of isoflurane and sevoflurane on synaptic transmission and synaptic plasticity (long-term potentiation, LTP) in the CA1 stratum radiatum of the hippocampus. Isoflurane and sevoflurane dose-dependently… CONTINUE READING
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