Isoflurane Preconditioning Increases Survival of Rat Skin Random-Pattern Flaps by Induction of HIF-1α Expression

@article{Sun2013IsofluranePI,
  title={Isoflurane Preconditioning Increases Survival of Rat Skin Random-Pattern Flaps by Induction of HIF-1$\alpha$ Expression},
  author={Y. Sun and Qi-fang Li and Y. Zhang and R. Hu and H. Jiang},
  journal={Cellular Physiology and Biochemistry},
  year={2013},
  volume={31},
  pages={579 - 591}
}
Background: Survival of random-pattern skin flaps is important for the success of plastic and reconstructive surgeries. This study investigates isoflurane-induced protection against ischemia of skin flap and the underlying molecular mechanism in this process. Methods: Human umbilical vein endothelial cells (HUVECs) and human skin fibroblast cells were exposed to isoflurane for 4 h. Expression of hypoxia inducible factor-1α (HIF-1α), heme oxygenase-1 (HO-1) and vascular endothelial growth factor… Expand
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Preconditioning with Foam-mediated External Suction on Flap Microvasculature and Perfusion in a Rodent Model
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