Isoflurane-Induced Caspase-3 Activation Is Dependent on Cytosolic Calcium and Can Be Attenuated by Memantine

  title={Isoflurane-Induced Caspase-3 Activation Is Dependent on Cytosolic Calcium and Can Be Attenuated by Memantine},
  author={Guohua Zhang and Y. Dong and B. Zhang and F. Ichinose and X. Wu and D. Culley and G. Crosby and R. Tanzi and Z. Xie},
  journal={The Journal of Neuroscience},
  pages={4551 - 4560}
  • Guohua Zhang, Y. Dong, +6 authors Z. Xie
  • Published 2008
  • Biology, Medicine
  • The Journal of Neuroscience
  • Increasing evidence indicates that caspase activation and apoptosis are associated with a variety of neurodegenerative disorders, including Alzheimer's disease. We reported that anesthetic isoflurane can induce apoptosis, alter processing of the amyloid precursor protein (APP), and increase amyloid-β protein (Aβ) generation. However, the mechanism by which isoflurane induces apoptosis is primarily unknown. We therefore set out to assess effects of extracellular calcium concentration on… CONTINUE READING
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