Isoflavonoid from Viola hondoensis, regulates the expression of matrix metalloproteinase-1 in human skin fibroblasts.

@article{Moon2005IsoflavonoidFV,
  title={Isoflavonoid from Viola hondoensis, regulates the expression of matrix metalloproteinase-1 in human skin fibroblasts.},
  author={Hyung In Moon and Joongku Lee and Jong Hwan Kwak and Ok-Pyo Zee and Jin Ho Chung},
  journal={Biological & pharmaceutical bulletin},
  year={2005},
  volume={28 5},
  pages={925-8}
}
Long term and repeated exposure of ultraviolet (UV) light, a harmful environmental stress, on the skin often induces chronic skin diseases such as skin cancer as well as photoaging (premature skin aging), and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinases (MMPs) activities. Here we investigated the effect of 2',4',7-trihydroxyisoflavone isolated from the whole plants of Viola hondoensis (Violaceae) on the expression of MMPs in UV… CONTINUE READING