Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice.

@article{Liu2015IsoflavonesIS,
  title={Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice.},
  author={Yunxian Liu and Leena Hilakivi-Clarke and Yukun Zhang and Xiao Wang and Yuan-Xiang Pan and Jianhua Xuan and Stefanie C. Fleck and Daniel R. Doerge and William G Helferich},
  journal={Molecular nutrition \& food research},
  year={2015},
  volume={59 8},
  pages={
          1419-30
        }
}
SCOPE Soy flour diet (MS) prevented isoflavones from stimulating MCF-7 tumor growth in athymic nude mice, indicating that other bioactive compounds in soy can negate the estrogenic properties of isoflavones. The underlying signal transduction pathways to explain the protective effects of soy flour consumption were studied here. METHODS AND RESULTS Ovariectomized athymic nude mice inoculated with MCF-7 human breast cancer cells were fed either Soy flour diet (MS) or purified isoflavone mix… 

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