Isoflavone Attenuates Vascular Contraction through Inhibition of the RhoA/Rho-Kinase Signaling Pathway

  title={Isoflavone Attenuates Vascular Contraction through Inhibition of the RhoA/Rho-Kinase Signaling Pathway},
  author={Young Mi Seok and Inji Baek and Yong-Hoon Kim and Yeon-Shin Jeong and In-Jung Lee and Dong-Hyun Shin and Y. H. Hwang and In Kyeom Kim},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={991 - 998}
  • Y. Seok, Inji Baek, I. Kim
  • Published 1 September 2008
  • Biology, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
Isoflavones decrease blood pressure, improve lipid profiles, and restore vascular function. We hypothesized that isoflavone attenuates vascular contraction by inhibiting RhoA/Rho-kinase signaling pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, and contracted with 11,9 epoxymethano-prostaglandin F2α (U46619), a thromboxane A2 analog, or KCl 30 min after the pretreatment with genistein (4′,5,7-trihydroxyisoflavone), daidzein (4′,7-dihydroxyisoflavone), or vehicle… 

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