Isoelectric focusing variant thyroxine-binding globulin in American blacks: increased heat lability and reduced serum concentration.

@article{Takamatsu1986IsoelectricFV,
  title={Isoelectric focusing variant thyroxine-binding globulin in American blacks: increased heat lability and reduced serum concentration.},
  author={Junta Takamatsu and Masanori Ando and Mitchell Weinberg and Samuel Refetoff},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1986},
  volume={63 1},
  pages={80-7}
}
Three major bands of T4-binding globulin (TBG) at pH 4.3-4.5 are seen after isoelectric focusing (IEF) of serum. Daiger et al. detected a cathodal shift of all IEF bands in some American blacks, and found that the inheritance of this variant TBG (TBG-S) is X-chromosome linked. However, the properties of the TBG-S molecule and its possible association with changes in thyroid function have not been studied. Based on IEF analysis of 114 serum samples from adult American blacks, the gene frequency… CONTINUE READING

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