Isodose-based methodology for minimizing the morbidity and mortality of thoracic hypofractionated radiotherapy.

@article{Gay2009IsodosebasedMF,
  title={Isodose-based methodology for minimizing the morbidity and mortality of thoracic hypofractionated radiotherapy.},
  author={Hiram A. Gay and Claudio H. Sibata and Ron R. Allison and Branislav Jeremic},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2009},
  volume={91 3},
  pages={369-78}
}
BACKGROUND AND PURPOSE Help identify and define potential normal tissue dose constraints to minimize the mortality and morbidity of hypofractionated lung radiotherapy. MATERIALS AND METHODS A method to generate isodose-based constraints and visually evaluate treatment plans, based on the published peer reviewed literature and the linear quadratic model, is presented. The radiobiological analysis assumes that the linear quadratic model is valid up to 28 Gy per fraction, the alpha/beta ratio is… CONTINUE READING

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