Isodiospyrin as a novel human DNA topoisomerase I inhibitor.

  title={Isodiospyrin as a novel human DNA topoisomerase I inhibitor.},
  author={C Ting and Chia-Tse Hsu and H Hsu and Jin-Shan Su and Tzong-Yueh Chen and Woan-Yuh Tarn and Y H Kuo and Jacqueline Whang-Peng and Leroy F. Liu and Jaulang Hwang},
  journal={Biochemical pharmacology},
  volume={66 10},
Isodiospyrin is a natural product from the plant Diospyros morrisiana, which consists of an asymmetrical 1,2-binaphthoquinone chromophore. Isodiospyrin exhibits cytotoxic activity to tumor cell lines but very little is known about its cellular target and mechanism of action. Unlike the prototypic human topoisomerase I (htopo I) poison camptothecin, isodiospyrin does not induce htopo I-DNA covalent complexes. However, isodiospyrin antagonizes camptothecin-induced, htopo I-mediated DNA cleavage… CONTINUE READING
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