Isodicentric Y Chromosomes and Sex Disorders as Byproducts of Homologous Recombination that Maintains Palindromes

@article{Lange2009IsodicentricYC,
  title={Isodicentric Y Chromosomes and Sex Disorders as Byproducts of Homologous Recombination that Maintains Palindromes},
  author={Julian Lange and Helen Skaletsky and Saskia K.M. van Daalen and Stephanie L. Embry and Cindy M. Korver and Laura Grace Brown and Robert D. Oates and Sherman Silber and Sjoerd Repping and David C. Page},
  journal={Cell},
  year={2009},
  volume={138},
  pages={855-869}
}
  • Julian Lange, Helen Skaletsky, +7 authors David C. Page
  • Published in Cell 2009
  • Biology, Medicine
  • Massive palindromes in the human Y chromosome harbor mirror-image gene pairs essential for spermatogenesis. During evolution, these gene pairs have been maintained by intrapalindrome, arm-to-arm recombination. The mechanism of intrapalindrome recombination and risk of harmful effects are unknown. We report 51 patients with isodicentric Y (idicY) chromosomes formed by homologous crossing over between opposing arms of palindromes on sister chromatids. These ectopic recombination events occur at… CONTINUE READING

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