Isocyanide insertion: de novo synthesis of trifluoromethylated phenanthridine derivatives.

@article{Cheng2013IsocyanideID,
  title={Isocyanide insertion: de novo synthesis of trifluoromethylated phenanthridine derivatives.},
  author={Yuanzheng Cheng and Heng Jiang and Yan Zhang and Shouyun Yu},
  journal={Organic letters},
  year={2013},
  volume={15 21},
  pages={
          5520-3
        }
}
A mechanistically new strategy has been described for the simple, practical, and environmentally friendly preparation of 6-(trifluoromethyl)phenanthridine derivatives using ionic isocyanide insertion from biphenyl isocyanide derivatives and Umemoto's reagent. These reactions were promoted only by inorganic base in good-to-excellent chemical yields without any external stoichiometric oxidants and radical initiators. 
97 Citations
Isocyanide Insertion: De novo Synthesis of Trifluoromethylated Phenanthridine Derivatives.
Ionic isocyanide insertion from biphenyl isocyanide derivative and Usemoto′s reagent (II) is developed resulting in an efficient synthesis of 6-trifluoromethyl substituted phenanthridines and a
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Synthesis of 6-aminophenanthridines via palladium-catalyzed insertion of isocyanides into N-sulfonyl-2-aminobiaryls
A robust route to a diverse set of 6-aminophenanthridines via palladium-catalyzed C–H activation of N-sulfonyl-2-aminobiaryl and isocyanide insertion is reported. This transformation could also
Synthesis of 6-(arylthio)phenanthridines by copper-catalyzed tandem reactions of 2-biaryl isothiocyanates with diaryliodonium salts.
TLDR
A novel copper-catalyzed tandem C-S/C-C bond-forming reaction of 2-biaryl isothiocyanates with diaryliodonium salts was developed and this methodology has been successfully applied to the synthesis of trisphaeridine.
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