Isoconazole nitrate: a unique broad‐spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids

  title={Isoconazole nitrate: a unique broad‐spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids},
  author={Stefano Veraldi},
Fungal skin infections, or dermatomycoses, are associated with a broad range of pathogens. Involvement of gram‐positive bacteria is often suspected in dermatomycoses. Inflammation plays an important role in dermatomycoses, displaying a close association between frequent inflammation and reduced skin‐related quality of life. Isoconazole nitrate (ISN) is a broad‐spectrum antimicrobial agent with a highly effective antimycotic and gram‐positive antibacterial activity, a rapid rate of absorption… 
Dermatomycoses and inflammation: The adaptive balance between growth, damage, and survival.
This review aims to compare the pathogenesis of common dermatomycotic species, including Candida yeasts (Candida albicans), dermatophytes (Trichophyton, Epidermophyton or Microsporum species), and other pathogenic Yeasts (Malassezia), with a special focus on unique species-specific aspects of the respective infection processes.
Efficacy of topical isoconazole nitrate in the treatment of otomycosis.
Isoconazole nitrate cream appears to be an effective and easily applicable agent for the treatment of otomycosis.
The association of isoconazole–diflucortolone in the treatment of pediatric tinea corporis
A study in atopic children with tinea corporis superinfected by S. aureus confirms that a topical therapy with the association isoconazole–diflucortolone is useful and safe.
Tacrolimus, not triamcinolone acetonide, interacts synergistically with itraconazole, terbinafine, bifonazole, and amorolfine against clinical dermatophyte isolates.
Compared with TRI, TAC showed better synergy when combined with antifungal agents, especially topical TRB and BIZ, against dermatophyte isolates.
Objective: To compare isoconazole nitrate versus nystatin for treatment of otomycosis. Study Design: Quasi experimental study. Place and Duration of Study: Combined Military Hospital Bahawalpur and
Clotrimazole multiple W/O/W emulsion as anticandidal agent: Characterization and evaluation on skin and mucosae.
CLT amounts retained in the skin and mucosae were also higher than commercial references, which coupled with the higher antimycotic efficacy make CLT-MEs a great tool for clinical investigation of topical candidiasis treatments.
Skin permeation of econazole nitrate formulated in an enhanced hydrophilic multiple emulsion
Multiple emulsions are a potential vehicle to enhance the delivery of econazole nitrate, an antifungal targeted to deep‐seated epidermal yeast infections, considered an improved approach to target the drug to deep epidermis.
Preparation of alginate–chitosan–cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds
It has been detected that alginate–chitosan–cyclodextrin microparticulate systems loaded with INH and ISN are as effective as pure INH applied in higher dosages.
Treatment of angular cheilitis: a narrative review and authors' clinical experience.
This group found in 1% isoconazole nitrate (ISN) and 0.1% diflucortolone valerate (DFV) ointment the most consistent AC treatment, due to the broad spectrum of ISN against many species of dermatohpytes and bacteria, and the anti-inflammatory properties displayed by DFV.
Composition pharmaceutique topique comprenant de l'acide fusidique, de l'isoconazole, du dexpanthénol et de l'hydrocortisone
La presente invention concerne un novueau produit de combinaison pharmaceutique topique comprenant de l'acide fusidique ou un sel pharmaceutiquement acceptable de celui-ci, de l'isoconazole ou un sel


The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses
Travocort® therapy showed a more rapid onset of action, faster relief of itch and other inflammatory symptoms, improved overall therapeutic benefits and better mycological cure rate during the first 2 weeks of treatment compared with ISN monotherapy, and is well tolerated and provides antifungal protection against reinfection for some weeks after therapy.
Update on azole antifungals.
Fluconazole remains a valuable low-cost choice for the treatment of various fungal infections, including candidiasis and cryptococcosis, and itraconazole exhibits significant activity against Aspergillus and the endemic fungi.
Topical therapy for dermatophytoses: should corticosteroids be included?
  • Z. Erbagci
  • Medicine
    American journal of clinical dermatology
  • 2004
Analysis of the literature documenting clinical study data and adverse reactions related to combination therapy drew the following conclusions: combination products containing a low potency nonfluorinated corticosteroid may initially be used for symptomatic inflamed lesions of tinea pedis, tinea corporis, and tinea cruris, in otherwise healthy adults with good compliance.
Overview of medically important antifungal azole derivatives
  • R. Fromtling
  • Medicine, Biology
    Clinical Microbiology Reviews
  • 1988
A major chemical group with antifungal activity, the azole derivatives, is examined and historical and state of the art information on the in vitro activity, experimental in vivo activity, mode of action, pharmacokinetics, clinical studies, and uses and adverse reactions are examined.
Sertaconazole: updated review of a topical antifungal agent
Sertaconazole is an imidazole-type antifungal agent that has shown considerable in vitro activity against pathogenic fungi and is also active against bacteria, mainly Gram-positive cocci, making it highly efficient in the treatment of polymicrobial infections.
Cutaneous infections dermatophytosis, onychomycosis, and tinea versicolor.
More research is needed to continue to develop drugs suitable for use in a broader range of patients and diagnostic tests that may be quicker or more specific than conventional ones and educate patients and physicians alike in faster recognition and treatment of dermatophytoses.
Miconazole, a pharmacological barrier to skin fungal infections
Miconazole is characterized by high safety, efficacy and versatility, and a unique, multifaceted nature of activity in the treatment of dermatomycoses, and exhibits a fungicidal effect against a number of fungal species, due to hydrogen peroxide accumulation.
Review on dermatomycosis: pathogenesis and treatment
Exploring the unexplored aspect of actinobacteria for developing antidermatophytic drugs is a novel attempt which needs further investigation.
[Antimicrobial activity of the broad spectrum antimycotic isoconazole nitrate in humans (author's transl)].
A comparative study (occlusion test according to Marples and Kligman) was conducted in 100 test subjects with several formulations of isoconazole nitrate and there were no differences in efficacy between the free base, isconazole, and the nitrate.
In vitro activity of seven azole compounds against some clinical isolates of non-dermatophytic filamentous fungi and some dermatophytes
The in vitro activity of seven azole compounds viz clotrimozole, isoconazole, bifanazoles, fluconazole oxyconazol, flu Conazole , bifonazole were comparable in their inhibitory activity against both dermatophytes and non-dermatophytes, and the azole derivatives, Bay n 7133 and Bay L 9139 showed higher MIC range.