Isoconazole nitrate: a unique broad‐spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids

@article{Veraldi2013IsoconazoleNA,
  title={Isoconazole nitrate: a unique broad‐spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids},
  author={Stefano Veraldi},
  journal={Mycoses},
  year={2013},
  volume={56}
}
Fungal skin infections, or dermatomycoses, are associated with a broad range of pathogens. Involvement of gram‐positive bacteria is often suspected in dermatomycoses. Inflammation plays an important role in dermatomycoses, displaying a close association between frequent inflammation and reduced skin‐related quality of life. Isoconazole nitrate (ISN) is a broad‐spectrum antimicrobial agent with a highly effective antimycotic and gram‐positive antibacterial activity, a rapid rate of absorption… 
Dermatomycoses and inflammation: The adaptive balance between growth, damage, and survival.
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This review aims to compare the pathogenesis of common dermatomycotic species, including Candida yeasts (Candida albicans), dermatophytes (Trichophyton, Epidermophyton or Microsporum species), and other pathogenic Yeasts (Malassezia), with a special focus on unique species-specific aspects of the respective infection processes.
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TLDR
Isoconazole nitrate cream appears to be an effective and easily applicable agent for the treatment of otomycosis.
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A study in atopic children with tinea corporis superinfected by S. aureus confirms that a topical therapy with the association isoconazole–diflucortolone is useful and safe.
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Objective: To compare isoconazole nitrate versus nystatin for treatment of otomycosis. Study Design: Quasi experimental study. Place and Duration of Study: Combined Military Hospital Bahawalpur and
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CLT amounts retained in the skin and mucosae were also higher than commercial references, which coupled with the higher antimycotic efficacy make CLT-MEs a great tool for clinical investigation of topical candidiasis treatments.
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TLDR
Multiple emulsions are a potential vehicle to enhance the delivery of econazole nitrate, an antifungal targeted to deep‐seated epidermal yeast infections, considered an improved approach to target the drug to deep epidermis.
Preparation of alginate–chitosan–cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds
TLDR
It has been detected that alginate–chitosan–cyclodextrin microparticulate systems loaded with INH and ISN are as effective as pure INH applied in higher dosages.
Treatment of angular cheilitis: a narrative review and authors' clinical experience.
TLDR
This group found in 1% isoconazole nitrate (ISN) and 0.1% diflucortolone valerate (DFV) ointment the most consistent AC treatment, due to the broad spectrum of ISN against many species of dermatohpytes and bacteria, and the anti-inflammatory properties displayed by DFV.
Composition pharmaceutique topique comprenant de l'acide fusidique, de l'isoconazole, du dexpanthénol et de l'hydrocortisone
La presente invention concerne un novueau produit de combinaison pharmaceutique topique comprenant de l'acide fusidique ou un sel pharmaceutiquement acceptable de celui-ci, de l'isoconazole ou un sel
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