Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight

  title={Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight},
  author={Hamoud H. Al-Khallaf},
  journal={Cell & Bioscience},
  • Hamoud H. Al-Khallaf
  • Published 2017
  • Biology, Medicine
  • Cell & Bioscience
  • Isocitrate dehydrogenases play important roles in cellular metabolism and cancer. This review will discuss how the roles of isoforms 1 and 2 in normal cell and cancer metabolism are distinct from those of isoform 3. It will also explain why, unlike 1 and 2, mutations in isoform 3 in tumor are not likely to be driver ones. A model explaining two important features of isocitrate dehydrogenases 1 and 2 mutations, their dominant negative effect and their mutual exclusivity, will be provided. The… CONTINUE READING
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