Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma.

@article{Agnihotri2014IsocitrateDS,
  title={Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma.},
  author={Sameer Agnihotri and Kenneth D. Aldape and Gelareh Mohammed Zadeh},
  journal={Neurosurgical focus},
  year={2014},
  volume={37 6},
  pages={E13}
}
Diffuse gliomas and secondary glioblastomas (GBMs) that develop from low-grade gliomas are a common and incurable class of brain tumor. Mutations in the metabolic enzyme glioblastomas (IDH1) represent a distinguishing feature of low-grade gliomas and secondary GBMs. IDH1 mutations are one of the most common and earliest detectable genetic alterations in low… CONTINUE READING