Isocitrate dehydrogenase mutations in gliomas.

@article{Waitkus2016IsocitrateDM,
  title={Isocitrate dehydrogenase mutations in gliomas.},
  author={Matthew S Waitkus and Bill H Diplas and Hai Yan},
  journal={Neuro-oncology},
  year={2016},
  volume={18 1},
  pages={16-26}
}
Over the last decade, extraordinary progress has been made in elucidating the underlying genetic causes of gliomas. In 2008, our understanding of glioma genetics was revolutionized when mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) were identified in the vast majority of progressive gliomas and secondary glioblastomas (GBMs). IDH enzymes normally catalyze the decarboxylation of isocitrate to generate α-ketoglutarate (αKG), but recurrent mutations at Arg(132) of IDH1 and Arg(172) of… CONTINUE READING

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