Isocitrate dehydrogenase mutations in gliomas.

  title={Isocitrate dehydrogenase mutations in gliomas.},
  author={Matthew S Waitkus and Bill H Diplas and Hai Yan},
  volume={18 1},
Over the last decade, extraordinary progress has been made in elucidating the underlying genetic causes of gliomas. In 2008, our understanding of glioma genetics was revolutionized when mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) were identified in the vast majority of progressive gliomas and secondary glioblastomas (GBMs). IDH enzymes normally catalyze the decarboxylation of isocitrate to generate α-ketoglutarate (αKG), but recurrent mutations at Arg(132) of IDH1 and Arg(172) of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 44 extracted citations


Publications referenced by this paper.
Showing 1-10 of 104 references

Somatic mosaic IDH1

TC Pansuriya, R van Eijk, P d’Adamo

Effective immuno - targeting of the IDH 1 mutation R 132 H in a murine model of intracranial glioma

SW Coons, PC Johnson, BW Scheithauer
Acta Neuropathol Commun • 2015

Similar Papers

Loading similar papers…