Isocitrate dehydrogenase mutations: a challenge to traditional views on the genesis and malignant progression of gliomas.

@article{Weller2011IsocitrateDM,
  title={Isocitrate dehydrogenase mutations: a challenge to traditional views on the genesis and malignant progression of gliomas.},
  author={Michael Weller and Wolfgang Wick and Andreas von Deimling},
  journal={Glia},
  year={2011},
  volume={59 8},
  pages={1200-4}
}
Isocitrate dehydrogenases (IDHs) convert isocitrate to α-ketoglutarate by oxidative decarboxylation and are thereby involved in multiple metabolic processes. Mutations in the genes encoding IDH1 and IDH2 were first reported in human gliomas in 2008 and later on also identified in a minority of patients with acute myeloid leukemia. The mutations universally affect codons 132 in IDH1 and 172 in IDH2 and result in decreased enzymatic activity. The oncogenic pathway triggered by IDH mutations may… CONTINUE READING