Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

Abstract

PURPOSE Unexpected mutations affecting the isocitrate dehydrogenase (IDH1) gene at codon 132 have been found in 12% of glioblastomas. PATIENTS AND METHODS IDH1 codon 132 sequencing was performed in a series of 404 patients with glioma (100 grade 2, 121 grade 3, and 183 grade 4 gliomas) and correlated with histology, genomic profile, methylguanyl… (More)
DOI: 10.1200/JCO.2009.21.9832

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