Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas.

Abstract

Recent work has identified novel point mutations in isocitrate dehydrogenase 1 (IDH1) in the majority of the World Health Organization grades II and III infiltrative gliomas and secondary grade IV glioblastomas. Gangliogliomas consist of neoplastic ganglion and glial cells and, in contrast to infiltrative gliomas, are generally indolent. Yet distinguishing… (More)
DOI: 10.1111/j.1750-3639.2011.00480.x

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