Isochromosomes in neoplasia.

  title={Isochromosomes in neoplasia.},
  author={Fredrik Mertens and Bertil Johansson and Felix Mitelman},
  journal={Genes, chromosomes & cancer},
  volume={10 4},
In order to ascertain the frequency and distribution of isochromosomes in neoplasia, we surveyed the cytogenetic data from 20,007 tumors with clonal chromosome aberrations reported in the literature. Tumor types for which at least 50 cases with acquired aberrations and 10 cases with isochromosomes had been reported were selected, yielding a total of 18,160 neoplasms. Of these, 1,792 cases (9.9%) displayed a total of 2,014 isochromosomes. The 9 most common isochromosomes (detected in at least 50… CONTINUE READING
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