Isochromans and Related Constituents from the Endophytic Fungus Annulohypoxylon truncatum of Zizania caduciflora and Their Anti-Inflammatory Effects.

  title={Isochromans and Related Constituents from the Endophytic Fungus Annulohypoxylon truncatum of Zizania caduciflora and Their Anti-Inflammatory Effects.},
  author={Wei Li and Changyeol Lee and Sunghee Bang and Jin Yeul Ma and Soonok Kim and Young Sang Koh and Sang Hee Shim},
  journal={Journal of natural products},
  volume={80 1},
Six new isochroman derivatives (annulohypoxylomans A-C, 1-3; annulohypoxylomanols A and B, 6 and 7; and annulohypoxyloside, 8), an isocoumarin (annulohypoxylomarin A, 4), and an azaphilone derivative (xylariphilone, 5) were isolated from an ethyl acetate extract derived from cultures of the endophytic fungus JS540 found in the leaves of Zizania caduciflora. The JS540 strain was identified as Annulohypoxylon truncatum. The structures of the isolated compounds were elucidated by one- and two… 

Figures and Tables from this paper

Chemical Constituents from Endophytic Fungus Annulohypoxylon cf. stygium in Leaves of Anoectochilus roxburghii

Sterigmatocystin and palmarumycin CP2 showed selective cytotoxic activities against HepG2, HeLa, MCF‐7 and HT‐29 and were isolated from Annulohypoxylon genus for the first time.

Anti-inflammatory effect of 3,7-dimethyl-1,8-hydroxy-6-methoxyisochroman via nuclear factor erythroid 2-like 2-mediated heme oxygenase-1 expression in lipopolysaccharide-stimulated RAW264.7 and BV2 cells

The results of this study suggest that DMHM inhibited several inflammatory pathways including the NF-κB and MAPK pathways, and induced Nrf2-mediated HO-1 expression, demonstrating its potential usefulness for treating inflammatory and neuroinflammatory diseases.

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

118 compounds and 6 extracts have been reported to be obtained from endophytic sources showing anti-inflammatory activities, and herbarin, periconianone A, and periconIANone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition.

2-Oxaspiro[4.5]decane and α-pyrenocine derivatives from the endophytic fungus Roussoella sp. PSU-H51

Abstract One new 2-oxaspiro[4.5]decane, roussoellide, and one new α-pyrenocine, 2',3'-dihydropyrenocine A, together with nine known compounds including known arthropsolide A, and pyrenocines A and E,

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019.

Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

  • R. Toghueo
  • Medicine, Biology
    Natural Products and Bioprospecting
  • 2019
The status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats is reviewed to help accelerate the drug discovery against leishmaniases and inflammation-associated disorders.

Recent advances in the chemistry and biology of azaphilones

A total of 252 compounds predominantly originated from 32 genera of fungi, such as Penicillium and Talaromyces, were included in this research, of which over 40% displayed cytotoxic/anti-tumor effects.

Stereoselective Synthesis of Oxacycles via Ruthenium-Catalyzed Atom-Economic Coupling of Propargyl Alcohols and Michael Acceptors.

A ruthenium-catalyzed atom-economic coupling of pent-2-yne-1,5-diols and Michael acceptors is described as an efficient route for the synthesis of β-hydroxyenones with excellent yields and high regioselectivity for tetrahydro-4H-pyran-4-ones.



A new radical scavenging anthracene glycoside, asperflavin ribofuranoside, and polyketides from a marine isolate of the fungus microsporum.

A new anthracene glycoside, asperflavin ribofuranoside (1), and the previously described polyketides, flavoglaucin (2), isodihydroauroglaucin (3), and citrinin (4) have been isolated from the

Novel antiplatelet naphthalene from Rhamnus nakaharai.

A new naphthalene derivative, isotorachrysone, was isolated from the stem bark of Rhamnus nakaharai along with several known compounds and showed potent antiplatelet effects on arachidonic acid (AA-) and collagen-induced platelet aggregation.

Differential analysis of mycoalexins in confrontation zones of grapevine fungal pathogens by ultrahigh pressure liquid chromatography/time-of-flight mass spectrometry and capillary nuclear magnetic resonance.

An original approach was developed for the chemical and biological investigation of zone lines formed by the confrontation of fungi growing in confined spaces and demonstrates the use of fungal confrontations as an original source of bioactive molecules and gives new insights into the study of esca disease.

Endophytic and epiphytic microbes as “sources” of bioactive agents

Examples from insects, plants, and marine invertebrates are given to give examples of how interactions within the macroorganism, or in certain cases, a fungus, ends up with the production of a novel agent that has potential as a treatment for a human disease.

Natural products from endophytic microorganisms.

The prospects of finding new drugs that may be effective candidates for treating newly developing diseases in humans, plants, and animals are great and other applications in industry and agriculture may also be discovered among the novel products produced by endophytic microbes.

Xylariphilone: a new azaphilone derivative from the seagrass-derived fungus Xylariales sp. PSU-ES163

One new azaphilone derivative, named xylariphilone (1), along with 10 known compounds was isolated from the seagrass-derived fungus Xylariales sp. PSU-ES163. Their structures were elucidated on the

Cytotoxic polyketides from a marine-derived fungus Aspergillus glaucus.

Eight new aromatic polyketides (2, 4-6, 8, 14, 16, and 17) together with eight known analogues (3, 7, 9-13, and 15) were isolated from the marine-derived fungus Aspergillus glaucus. The structures

Bioactive Endophytes Warrant Intensified Exploration and Conservation

This study provides direct evidence from bioassays of endophytes isolated from tropical plants and bioinformatic analyses that novel biology will indeed yield novel chemistry of potential value and highlights the hidden hyperdiversity ofendophytic fungi and the urgent need to explore and conserve hidden microbial diversity.