Isochores and the evolutionary genomics of vertebrates.

@article{Bernardi2000IsochoresAT,
  title={Isochores and the evolutionary genomics of vertebrates.},
  author={Giorgio Bernardi},
  journal={Gene},
  year={2000},
  volume={241 1},
  pages={3-17}
}
The nuclear genomes of vertebrates are mosaics of isochores, very long stretches (>>300kb) of DNA that are homogeneous in base composition and are compositionally correlated with the coding sequences that they embed. Isochores can be partitioned in a small number of families that cover a range of GC levels (GC is the molar ratio of guanine+cytosine in DNA), which is narrow in cold-blooded vertebrates, but broad in warm-blooded vertebrates. This difference is essentially due to the fact that the… CONTINUE READING
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