Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.

@article{Parsons1988IsobutylmethylxanthineSA,
  title={Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.},
  author={William F. J. Parsons and Vickram Ramkumar and Gary L. Stiles},
  journal={Molecular pharmacology},
  year={1988},
  volume={34 1},
  pages={37-41}
}
The methylxanthines, such as caffeine and theophylline, are an important and widely used class of drugs, which are believed to mediate many of their physiological effects by increasing intracellular concentrations of cAMP. These agents are known to inhibit phosphodiesterases and to block inhibitory A1 adenosine receptors in a competitive manner. Thus, the methylxanthines may increase cAMP accumulation by slowing its inactivation or by enhancing its production. Using a rat adipocyte membrane… CONTINUE READING
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