Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins.

@article{Mamula1999IsoaspartylPM,
  title={Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins.},
  author={Mark J. Mamula and Renelle J. Gee and James Isaac Elliott and Alessandro Sette and Scott Southwood and Peter John Vaughan Jones and Peter R. Blier},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 32},
  pages={
          22321-7
        }
}
The normal functioning immune system is programmed to attack foreign pathogens and other foreign proteins while maintaining tolerance to self-proteins. The mechanisms by which tolerance is broken in the initiation of autoimmunity are not completely understood. In the present study, mice immunized with the murine cytochrome c peptide 90-104 showed no response by the B or T cell compartments. However, immunization with the isoaspartyl form of this peptide, where the linkage of Asp(93) to Leu(94… CONTINUE READING

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