Isoaspartate formation and neurodegeneration in Alzheimer's disease.

  title={Isoaspartate formation and neurodegeneration in Alzheimer's disease.},
  author={Tomokazu Shimizu and Atsushi Watanabe and Midori Ogawara and Haruhide Mori and Takuji Shirasawa},
  journal={Archives of biochemistry and biophysics},
  volume={381 2},
We reviewed here that protein isomerization is enhanced in amyloid-beta peptides (Abeta) and paired helical filaments (PHFs) purified from Alzheimer's disease (AD) brains. Biochemical analyses revealed that Abeta purified from senile plaques and vascular amyloid are isomerized at Asp-1 and Asp-7. A specific antibody recognizing isoAsp-23 of Abeta further suggested the isomerization of Abeta at Asp-23 in vascular amyloid as well as in the core of senile plaques. Biochemical analyses of purified… CONTINUE READING


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