Iso-renin of extrarenal origin. "The tissue angiotensinogenase systems".

  title={Iso-renin of extrarenal origin. "The tissue angiotensinogenase systems".},
  author={Detlev Ganten and Pierre Schelling and Paul Vecsei and Ursula Ganten},
  journal={The American journal of medicine},
  volume={60 6},

The tissue renin-angiotensin systems: focus on brain angiotensin, adrenal gland and arterial wall.

The possibility of local generation of angiotensin in these target tissues, where it has marked biological effects casts a new light on ang Elliotensin as a more ubiquitous tissue factor or even a neurohormone.

Cellular biology of the renin-angiotensin systems.

  • R. Re
  • Biology
    Archives of internal medicine
  • 1984
Evidence suggests that renin can be synthesized at local tissue sites and that these local renin-angiotensin systems subserve important physiologic functions.

Renin exists in high concentration in the adrenal gland of the rat

The adrenal gland was found to have the highest true renin activity per unit weight of protein among the various extrarenal tissues and the pH optimum of this adrenal renin was approximately 7.0, suggesting a control mechanism for adrenal function mediated by an intraadrenal ren in-angiotensin system in addition to the plasma renin-angiotsin system.

Renin exists in human adrenal tissue.

An adrenal gland that was surgically removed from a patient with Cushing's disease and had high renin activity was used for further characterization of the enzyme, and the lack of correlation between PRA and the adrenal renin suggested its local origin rather than contamination or contribution of the plasma enzyme.

The Vascular Renin System

Studies with angiotensin-converting enzyme (ACE) inhibitors, and more recently with specific AII receptor antagonists, have demonstrated that even when the circulating levels are low, AII remains a major regulator of many biological responses, including blood pressure.

Adrenal renin: A possible local hormonal regulator of aldosterone production

The renin-angiotensin system has the highest activity in the zona glomerulosa cells, the site of aldosterone formation, and may be a local regulator of a Aldosterone production.

Renin-angiotensin system.

The renin-angiotensin system in human testis is demonstrated by measuring the plasma renin activity (PRA), plasma angiotens in II (PAII), and testosterone in the internal spermatic vein (ISV) simultaneously after treatment with hCG, and the relationship between the renIn-angiotsin system and sex steroids from Leydig cells of the male gonad is elucidated.

A renin-like enzyme in luteal tissue

Coexpression of renin, angiotensinogen, and their messenger ribonucleic acids in adrenal tissues.

It is demonstrated that renin and angiotensinogen are coexpressed in normal and pathological tissues and there was no obvious relationship between the expression of these proteins and the pathophysiology of the adrenal gland.

Vascular Renin-Angiotensin System and Renovascular Hypertension

Evidence demonstrating the presence of renin and renin-like activity within the blood vessel wall, the source and possible physiological role of this material and the part which it plays in the pathogenesis of renovascular hypertension are considered.


New aspects of the tissue iso-renin angiotensin systems (iso-RAS) in extrarenal tissue are presented as a local cellular enzymatic system.

Renin in heart muscle and arterial tissue.

It is reported that the brain of brain of dogs contains a complete renin-angiotensin being present in this tissue when their origin from the kidney is excluded and new findings on iso-renins in arterial tissue and heart muscle of dogs are reported.


A new enzyme, pseudorenin, has been discovered which resembles renin in its ability to form angiotensin I from the synthetic tetradecapeptide renin substrate and from purified hog renin substrate A.

Pseudorenin. A new angiotensin-forming enzyme.

A new enzyme, pseudorenin, has been discovered which resembles renin in its ability to form angiotensin I from the synthetic tetradecapeptide renin substrate and from purified hog renin substrate A.


The preparation, of an extract of hog blood vessels and organs containing renin activity, hydrolyzes natural or synthetic renin substrate to form a vasopressor material, which could not be distinguished from the hydrolysis of renin substrates by kidney renin.


An enzyme with the characteristics of classical renin was isolated from brain extracts of nephrectomized dogs and a remarkable correlation was found between angiotensin and norepinphrine concentrations in different portions of the encephalon of the dog.

The Biological Production of Angiotensin

The reaction of kidney renin with its plasma substrate to form angiotensin has been studied for many years using both crude and purified materials derived from many species. Much effort has been

Studies on the Characterization of Pure Submaxillary Gland Renin 1

Summary The effect of the recently obtained pure submaxillary gland renin on blood pressure and its action on rat plasma renin substrate to generate angiotensin were studied. Administration of

Characterization and source of a renin-like enzyme in anephric humans.

Biochemical properties including chromatographic characteristics, the velocity curve for angiotensin formation and Michaelis-Menten Constants, indicate that the extrarenal renin was indistinguishable from human renal renin.