Iso-osmolar prehydration shifts the cytokine response towards a more anti-inflammatory balance in human endotoxemia.

@article{Dorresteijn2005IsoosmolarPS,
  title={Iso-osmolar prehydration shifts the cytokine response towards a more anti-inflammatory balance in human endotoxemia.},
  author={Mirrin Josefien Dorresteijn and Lucas TGJ van Eijk and Mihai G Netea and P. G. F. M. Smits and Johannes G Van der Hoeven and Peter Pickkers},
  journal={Journal of endotoxin research},
  year={2005},
  volume={11 5},
  pages={287-93}
}
Clinical experience suggests that the administration of fluids in human endotoxemia reduces symptoms. In the present study, the effects of a standardised fluid protocol on symptoms, inflammatory and hemodynamic parameters in human endotoxemia are determined. With approval of the local ethics committee, 16 healthy volunteers received 2 ng/kg of Escherichia coli endotoxin (O:113). After an overnight fast, nine subjects received 1.5 l of 2.5% glucose/0.45% NaCl the hour prior to the endotoxin… CONTINUE READING
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