Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells.

@article{Monti2008IsletTI,
  title={Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells.},
  author={Paolo Monti and Miriam Scirpoli and Paola Maffi and Nadia Ghidoli and Francesca de Taddeo and F. Bertuzzi and Lorenzo Piemonti and Marika Falcone and Antonio Secchi and Ezio Bonifacio},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 5},
  pages={1806-14}
}
Successful transplantation requires the prevention of allograft rejection and, in the case of transplantation to treat autoimmune disease, the suppression of autoimmune responses. The standard immunosuppressive treatment regimen given to patients with autoimmune type 1 diabetes who have received an islet transplant results in the loss of T cells. In many other situations, the immune system responds to T cell loss through cytokine-dependant homeostatic proliferation of any remaining T cells… CONTINUE READING
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CD 8 + T - cell responses identify beta - cell autoimmunity in human type 1

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CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes

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