Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.

  title={Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.},
  author={Marc Yves Donath and Marianne B{\"o}ni-Schnetzler and Helga Ellingsgaard and Jan Adam Ehses},
Onset of Type 2 diabetes occurs when the pancreatic beta-cell fails to adapt to the increased insulin demand caused by insulin resistance. Morphological and therapeutic intervention studies have uncovered an inflammatory process in islets of patients with Type 2 diabetes characterized by the presence of cytokines, immune cells, beta-cell apoptosis, amyloid deposits, and fibrosis. This insulitis is due to a pathological activation of the innate immune system by metabolic stress and governed by… CONTINUE READING


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