Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat.

@article{HomoDelarche2006IsletIA,
  title={Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat.},
  author={Françoise Homo-Delarche and Sophie Cald{\'e}rari and J. -C. Irminger and Marie-N{\"o}elle Gangnerau and Josiane Coulaud and Katharina Rickenbach and Manuel Dolz and Philippe A. Halban and Bernard Portha and Patricia Serradas},
  journal={Diabetes},
  year={2006},
  volume={55 6},
  pages={1625-33}
}
The molecular pathways leading to islet fibrosis in diabetes are unknown. Therefore, we studied gene expression in islets of 4-month-old Goto-Kakizaki (GK) and Wistar control rats. Of 71 genes found to be overexpressed in GK islets, 24% belong to extracellular matrix (ECM)/cell adhesion and 34% to inflammatory/immune response families. Based on gene data, we selected several antibodies to study fibrosis development during progression of hyperglycemia by immunohistochemistry. One-month-old GK… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 74 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Chronic hyperglycemia is associated with an inflammatory islet reaction in a spontaneous model of type 2 diabetes (T2D) (Abstract)

F Homo-Delarche, S Calderari, +5 authors P Serradas
Diabetologia 48 (Suppl. 1):A180, • 2005

Endothelial cell regulation of matrix metalloproteinases.

Canadian journal of physiology and pharmacology • 2005

Similar Papers

Loading similar papers…