Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes

@article{Joerns2013IsletIC,
  title={Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes},
  author={Anne Joerns and Tanja Arndt and Andreas Meyer zu Vilsendorf and J{\"u}rgen Klempnauer and Dirk Wedekind and H. -J Hedrich and Lorella Marselli and Piero Marchetti and Nagakatsu Harada and Yutaka Nakaya and Gen-sheng Wang and Fraser W. Scott and Conny A. Gysemans and Chantal Mathieu and Sigurd Lenzen},
  journal={Diabetologia},
  year={2013},
  volume={57},
  pages={512-521}
}
Aims/hypothesisResearch on the pathogenesis of type 1 diabetes relies heavily on good animal models. The aim of this work was to study the translational value of animal models of type 1 diabetes to the human situation.MethodsWe compared the four major animal models of spontaneous type 1 diabetes, namely the NOD mouse, BioBreeding (BB) rat, Komeda rat and LEW.1AR1-iddm rat, by examining the immunohistochemistry and in situ RT-PCR of immune cell infiltrate and cytokine pattern in pancreatic… CONTINUE READING
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in the spontaneously diabetic LEW . 1 AR 1 / Ztm - iddm rat

T Arndt, A Jörns, H Weiss
  • 2013

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