Islet gene expression and function in type 2 diabetes; studies in the Goto-Kakizaki rat and humans.

@article{Ostenson2007IsletGE,
  title={Islet gene expression and function in type 2 diabetes; studies in the Goto-Kakizaki rat and humans.},
  author={C-G Ostenson and Suad Efendi{\'c}},
  journal={Diabetes, obesity & metabolism},
  year={2007},
  volume={9 Suppl 2},
  pages={
          180-6
        }
}
Defective beta-cell function with resulting impairment of glucose-stimulated insulin release is a critical factor in the pathogenesis of type 2 diabetes. Accumulated studies in pancreatic islets of the spontaneously diabetic Goto-Kakizaki (GK) rat suggest that this is a useful animal model of type 2 diabetes. The GK rat is non-obese, and abnormal glucose regulation develops early in life in association with impaired insulin secretion. There are some differences in islet morphology and function… CONTINUE READING

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