Islet cell neogenesis in the pancreas

  title={Islet cell neogenesis in the pancreas},
  author={Luc Bouwens and G{\"o}unter Kl{\"o}ppel},
  journal={Virchows Archiv},
The beta cell population of the endocrine pancreas may expand by either of two processes, neogenesis or replication. While replication requires the existence of an already differentiatied beta cell, neogenesis depends on the presence of active stem cells. Since the replicative activity of highly specialized cells such as beta cells seems to be limited, it is interesting to study the potential of the endocrine pancreas for beta cell neogenesis. In this article we review both the current state of… CONTINUE READING