Islet biology, the CDKN2A/B locus and type 2 diabetes risk

  title={Islet biology, the CDKN2A/B locus and type 2 diabetes risk},
  author={Yahui Kong and Rohit B. Sharma and Benjamin Udoka Nwosu and Laura C Alonso},
Type 2 diabetes, fuelled by the obesity epidemic, is an escalating worldwide cause of personal hardship and public cost. Diabetes incidence increases with age, and many studies link the classic senescence and ageing protein p16INK4A to diabetes pathophysiology via pancreatic islet biology. Genome-wide association studies (GWASs) have unequivocally linked the CDKN2A/B locus, which encodes p16 inhibitor of cyclin-dependent kinase (p16INK4A) and three other gene products, p14 alternate reading… CONTINUE READING
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