Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes

@article{Giannopoulou2015IsletAP,
  title={Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes},
  author={Eleni Giannopoulou and C. Jurincic Winkler and Ruth Chmiel and Claudia Matzke and Marlon Scholz and Andreas Beyerlein and Peter Achenbach and Ezio Bonifacio and Anette-G. Ziegler},
  journal={Diabetologia},
  year={2015},
  volume={58},
  pages={2317-2323}
}
Autoantibodies that precede type 1 diabetes frequently develop in early childhood and target distinct beta cell proteins. The aim of this study was to determine the heterogeneity of islet autoantibody development and fate. The ages of development of insulin autoantibodies (IAA) and GAD autoantibodies (GADA), followed by multiple islet autoantibodies and progression to diabetes were examined in 2,441 children participating in two German birth cohorts. In 218 children who developed islet… CONTINUE READING

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Detection of antibodies directed to the N-terminal region of GAD is dependent on assay format and contributes to differences in the specificity of GAD autoantibody assays for type 1 diabetes

  • WilliamsAJK, LampasonaV, M Schlosser
  • Diabetes. doi:10
  • 2015
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