Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats

@article{Mulder1996IsletAP,
  title={Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats},
  author={Dr. H. Mulder and Bo Ahr{\'e}n and Frank Sundler},
  journal={Diabetologia},
  year={1996},
  volume={39},
  pages={649-657}
}
Islet amyloid polypeptide (IAPP) is over-expressed relative to insulin under several experimental conditions relevant to diabetes mellitus, including the immediate phase (7 days) following induction of streptozotocin diabetes. In the present study, IAPP and insulin gene expression were examined in chronic streptozotocin diabetes (3 weeks) in rats. Quantitative in situ hybridization, determining grain areas and optical densities of mRNA labelling, revealed that IAPP and insulin expression were… CONTINUE READING