Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.

@article{Wang2001IsletAD,
  title={Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.},
  author={Feng Wang and Rebecca L Hull and Josep Vidal and Miriam Cnop and Steven E Kahn},
  journal={Diabetes},
  year={2001},
  volume={50 11},
  pages={2514-20}
}
Islet amyloid occurs in >90% of type 2 diabetic patients and may play a role in the pathogenesis of this disease. To determine whether islet amyloid occurs diffusely throughout the pancreas, whether it affects islets equally, and whether it decreases islet endocrine cells, we characterized islet amyloidosis by computerized fluorescence microscopy in transgenic mice that develop typical islet amyloid. These mice produce the unique amyloidogenic component of human islet amyloid, human islet… CONTINUE READING