Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

@article{Kahn1999IsletAA,
  title={Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.},
  author={Steven E Kahn and Sofianos Andrikopoulos and C Bruce Verchere},
  journal={Diabetes},
  year={1999},
  volume={48 2},
  pages={241-53}
}
Islet amyloid has been recognized as a pathological entity in type 2 diabetes since the turn of the century. It has as its unique component the islet beta-cell peptide islet amyloid polypeptide (IAPP), or amylin, which is cosecreted with insulin. In addition to this unique component, islet amyloid contains other proteins, such as apolipoprotein E and the heparan sulfate proteoglycan perlecan, which are typically observed in other forms of generalized and localized amyloid. Islet amyloid is… CONTINUE READING

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