Islet Neogenesis Associated Protein (INGAP) induces the differentiation of an adult human pancreatic ductal cell line into insulin-expressing cells through stepwise activation of key transcription factors for embryonic beta cell development.

@article{AssoulineThomas2015IsletNA,
  title={Islet Neogenesis Associated Protein (INGAP) induces the differentiation of an adult human pancreatic ductal cell line into insulin-expressing cells through stepwise activation of key transcription factors for embryonic beta cell development.},
  author={B{\'e}atrice Assouline-Thomas and Daniel M. Ellis and Maria S Petropavlovskaia and Julia Makhlin and Jieping Ding and Lawrence Rosenberg},
  journal={Differentiation; research in biological diversity},
  year={2015},
  volume={90 4-5},
  pages={77-90}
}
Regeneration of β-cells in diabetic patients is an important goal of diabetes research. Islet Neogenesis Associated Protein (INGAP) was discovered in the partially duct-obstructed hamster pancreas. Its bioactive fragment, pentadecapeptide 104-118 (INGAP-P), has been shown to reverse diabetes in animal models and to improve glucose homeostasis in patients with diabetes in clinical trials. Further development of INGAP as a therapy for diabetes requires identification of target cells in the… CONTINUE READING