Isepamicin (SCH 21420, 1-N-HAPA gentamicin B): microbiological characteristics including antimicrobial potency of spectrum of activity.

@article{Jones1995Isepamicin2,
  title={Isepamicin (SCH 21420, 1-N-HAPA gentamicin B): microbiological characteristics including antimicrobial potency of spectrum of activity.},
  author={Ronald N. Jones},
  journal={Journal of chemotherapy},
  year={1995},
  volume={7 Suppl 2},
  pages={7-16}
}
Isepamicin (formerly SCH 21420 or 1-N-HAPA-gentamicin B) is a novel broad-spectrum aminoglycoside which possesses a high level of stability to aminoglycoside inactivating enzymes and low levels of toxicity to the kidney and inner ear. The only modifying enzymes capable of inactivating isepamicin are ANT(4')-I (staphylococci), ANT(4')-II and APH(3')-VI, in addition to resistance mediated by permeability mutations. The spectrum of isepamicin is most similar to that of amikacin, another… CONTINUE READING

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