Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells.

@article{Caballero2007IschemicVD,
  title={Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells.},
  author={S Baulies Caballero and Nilanjana Sengupta and Aqeela Afzal and K Chang and Sergio Li Calzi and Dennis L. Guberski and Timothy S Kern and Maria B Grant},
  journal={Diabetes},
  year={2007},
  volume={56 4},
  pages={960-7}
}
Endothelial precursor cells (EPCs) play a key role in vascular repair and maintenance, and their function is impeded in diabetes. We previously demonstrated that EPCs isolated from diabetic patients have a profound inability to migrate in vitro. We asked whether EPCs from normal individuals are better able to repopulate degenerate (acellular) retinal capillaries in chronic (diabetes) and acute (ischemia/reperfusion [I/R] injury and neonatal oxygen-induced retinopathy [OIR]) animal models of… CONTINUE READING

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