Ischemic stroke activates hematopoietic bone marrow stem cells.

  title={Ischemic stroke activates hematopoietic bone marrow stem cells.},
  author={Gabriel Courties and Fanny E Herisson and Hendrik B. Sager and Timo Heidt and Yuxiang Ye and Ying Wei and Yuan Sun and Nicolas Severe and Partha Dutta and Jennifer Scharff and David T Scadden and Ralph Weissleder and Filip K Swirski and Michael A. Moskowitz and Matthias Nahrendorf},
  journal={Circulation research},
  volume={116 3},
RATIONALE The mechanisms leading to an expanded neutrophil and monocyte supply after stroke are incompletely understood. OBJECTIVE To test the hypothesis that transient middle cerebral artery occlusion (tMCAO) in mice leads to activation of hematopoietic bone marrow stem cells. METHODS AND RESULTS Serial in vivo bioluminescence reporter gene imaging in mice with tMCAO revealed that bone marrow cell cycling peaked 4 days after stroke (P<0.05 versus pre tMCAO). Flow cytometry and cell cycle… CONTINUE READING
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