Ischemic preconditioning triggers tyrosine kinase signaling: a potential role for MAPKAP kinase 2.

@article{Maulik1998IschemicPT,
  title={Ischemic preconditioning triggers tyrosine kinase signaling: a potential role for MAPKAP kinase 2.},
  author={Nilanjana Maulik and Tetsuya Yoshida and Y L Zu and Motoaki Sato and Anirban Banerjee and Dipak Kumar Das},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1998},
  volume={275 5},
  pages={H1857-H1864}
}
Myocardial adaptation to ischemia has been shown to activate protein tyrosine kinase, potentiating activation of phospholipase D, which leads to the stimulation of mitogen-activated protein (MAP) kinases and MAP kinase-activated protein (MAPKAP) kinase 2. The present study sought to further examine the signal transduction pathway for the MAPKAP kinase 2 activation during ischemic adaptation. Isolated perfused rat hearts were adapted to ischemic stress by repeated ischemia and reperfusion… CONTINUE READING

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