Ischemic preconditioning protects against gap junctional uncoupling in cardiac myofibroblasts.

@article{Sundset2004IschemicPP,
  title={Ischemic preconditioning protects against gap junctional uncoupling in cardiac myofibroblasts.},
  author={Rune Sundset and Marie A. Cooper and Svein-Ole Mikalsen and Kirsti Ytrehus},
  journal={Cell communication & adhesion},
  year={2004},
  volume={11 2-4},
  pages={51-66}
}
Ischemic preconditioning increases the heart's tolerance to a subsequent longer ischemic period. The purpose of this study was to investigate the role of gap junction communication in simulated preconditioning in cultured neonatal rat cardiac myofibroblasts. Gap junctional intercellular communication was assessed by Lucifer yellow dye transfer. Preconditioning preserved intercellular coupling after prolonged ischemia. An initial reduction in coupling in response to the preconditioning stimulus… CONTINUE READING