Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity.

@article{Ping1997IschemicPI,
  title={Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity.},
  author={Peipei Ping and Jing Zhang and Yumin Qiu and Xiufeng Tang and Srinivas Manchikalapudi and Xian Cao and Roberto Bolli},
  journal={Circulation research},
  year={1997},
  volume={81 3},
  pages={404-14}
}
Considerable controversy surrounds the role of protein kinase C (PKC) in ischemic preconditioning (PC). Previous studies have used pharmacological agents and/or measured total myocardial PKC activity; however, no information is available regarding the effects of PC on individual isoforms in vivo. We performed a comprehensive evaluation (using Western immunoblotting) of the expression and subcellular distribution of all 11 currently known PKC isoforms in the heart of conscious rabbits subjected… CONTINUE READING
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