Ischemic preconditioning in humans: models, mediators, and clinical relevance.

  title={Ischemic preconditioning in humans: models, mediators, and clinical relevance.},
  author={Fabrizio Tomai and Filippo Crea and Luigi Chiariello and Pier Agostino Gioffr{\`e}},
  volume={100 5},
Ischemic preconditioning, a powerful form of endogenous protection against myocardial infarction, has been demonstrated in several animal species and, recently, in isolated human cardiomyocytes. For both logistic and ethical reasons, no clinical study can meet the strict conditions of experimental studies on preconditioning with infarct size as the end-point. Nevertheless, the demonstration of adaptation to ischemia observed during in vitro studies on human atrial trabeculae, in patients in the… CONTINUE READING
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