Ischemic preconditioning depends on interaction between mitochondrial KATP channels and actin cytoskeleton.

@article{Baines1999IschemicPD,
  title={Ischemic preconditioning depends on interaction between mitochondrial KATP channels and actin cytoskeleton.},
  author={Christopher P. Baines and Guang Shan Liu and Mustafa Birincioğlu and Stuart D. Critz and Michael V. Cohen and James M. Downey},
  journal={The American journal of physiology},
  year={1999},
  volume={276 4 Pt 2},
  pages={H1361-8}
}
Both mitochondrial ATP-sensitive K+ (KATP) channels and the actin cytoskeleton have been proposed to be end-effectors in ischemic preconditioning (PC). For evaluation of the participation of these proposed end effectors, rabbits underwent 30 min of regional ischemia and 3 h of reperfusion. PC by 5-min ischemia + 10-min reperfusion reduced infarct size by 60%. Diazoxide, a mitochondrial KATP-channel opener, administered before ischemia was protective. Protection was lost when diazoxide was given… CONTINUE READING

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