Ischemic preconditioning attenuates hypoperfusion after retinal ischemia in rats.

@article{Lin1999IschemicPA,
  title={Ischemic preconditioning attenuates hypoperfusion after retinal ischemia in rats.},
  author={James J. Lin and Steven Roth},
  journal={Investigative ophthalmology & visual science},
  year={1999},
  volume={40 12},
  pages={2925-31}
}
PURPOSE Retinal blood flow (RBF) was measured in rats to test the hypotheses that hypoperfusion follows severe ischemia in the retina and that ischemic preconditioning (IPC) attenuates this change in blood flow. METHODS Male Sprague-Dawley rats were anesthetized with halothane and mechanically ventilated by tracheostomy to maintain normocarbia and normoxia. Retinal ischemia was induced for 0, 5, 30, 60, 75, or 90 minutes. RBF was measured 60 and 150 minutes after the end of ischemia using the… CONTINUE READING